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Extra info for Acute Coronary Syndromes in Clinical Practice
The importance of the 3 redox proteins cytochrome 6, cl, and Rieske ironsulfur protein to complex III function is underscored by their primary role in both electron transfer and accompanying proton translocation, as well as by the fact that the corresponding be 1 complex in bacteria contains only these 3 proteins. Mitochondrial Bioenergetics in the Heart 33 Structural studies demonstrated that the functional be 1 complex is present as a dimer . Each monomer contains 13 transmembrane helices, 8 contributed by cytochrome 6, 1 from cytochrome c\ and 1 from the iron-sulfur protein.
J Child Neurol 15:357-61 27. Matthews PM, Marchington DR, Squier M, Land J, Brown R, Brown GK (1993) Molecular genetic characterization of an X-linked form of Leigh's syndrome. Ann Neurol 33:652-5 28. Bourgeron T, Rustin P, Chretien D, Birch-Machin M, Bourgeois M, Viegas-Pequignot E, Munnich A, Rotig A (1995) Mutation of a nuclear succinate dehydrogenase gene results in mitochondrial respiratory chain deficiency. Nat Genet 11:144-9 29. Filiano JJ, Goldenthal MJ, Mamourian AC, Hall CC, MarinGarcia J (2002) Mitochondrial DNA depletion in Leigh syndrome.
A. A. A. 32 aa 25 aa 40 aa None None 44 MITOCHONDRIA AND THE HEART There are two tissue-specific isoforms identified for the y gene, and these are derived from a single gene by alternative splicing of exon 9 . The H isoform is prevalent in cardiac and skeletal muscle, whereas the L isoform that contains additional sequences at its Cterminus is found in other tissues. The gene for the 8 subunit also uses alternative splicing to generate two transcripts whose differential function and expression are unknown .
Acute Coronary Syndromes in Clinical Practice